| Pair Name | Chebulagic acid, Doxorubicin | ||
| Phytochemical Name | Chebulagic acid (PubChem CID: 250397 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Chebulagic acid, Doxorubicin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Gene Regulation | Down-regulation | Expression | PTGS2 | hsa5743 |
| Down-regulation | Expression | ABCB1 | hsa5243 | |
| Down-regulation | Expression | NFKB1 | hsa4790 | |
| Down-regulation | Activity | MAPK1 | hsa5594 | |
| Down-regulation | Activity | MAPK8 | hsa5599 | |
| Down-regulation | Activity | MAPK14 | hsa1432 | |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| Result | The present study shows the efficacy of CA to overcome MDR-1 mediated drug resistance in HepG2 cells through COX-2 dependant modulation of MDR-1. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Chebulagic acid synergizes the cytotoxicity of doxorubicin in human hepatocellular carcinoma through COX-2 dependant modulation of MDR-1. Med Chem. 2011 Sep;7(5):432-42. doi: 10.2174/157340611796799087. | Click |
